Compound
collections

IMAX Discovery offers its clients and partners the opportunity to access:

  • a proprietary natural compound collection of about 100,000 individual test samples comprising 13,500 pure natural compounds (NatPure), 63,000 purified fractions (PreFrac) and 21,200 pre-purified extracts (Advanced Extracts)
  • a synthetic compound collection consisting of 325,000 compounds characterized by a high level of novelty and diversity

Comprehensive access to nature’s chemical diversity
(plants, fungi, microbial strains)

✔ NatPure Library
(13,500 pure compounds)

✔ PreFrac Library
(63,000 samples)

✔ Advanced Extract Library
(21,200 samples)

✔ Microbial Strain Library
(40,000 microbial strains)

IMAX Bioprofiling
(biological activity data)

NatPure Library

The worldwide largest pure natural product compound collection available consisting of around 13.500 pure compounds derived from plant and microbial sources, suitable for screening purposes.

Key features:

  • Approximately 30% are novel compounds, i.e. unpublished, by comparison with the Dictionary of Natural Products
  • High chemical diversity guaranteed by preselection of biological sources. Contains around 4.900 distinct chemical clusters
  • Adheres to the Convention on Biological Diversity (CBD)
  • Comprehensive analytical characterization
  • Linked to IMAX BIOPROFILING database
  • Pre-plated in 384 well plates, as DMSO solutions, fully HTS compatible

PreFrac Library

A collection of around 63.000 purified fractions (containing each from 3 to 6 compounds) derived from distinct microbial extracts.

Key features:

  • 63.000 fractions derived from around 750 individual strains
  • 53% bacterial sources
  • 47% fungal sources
  • Adheres to the Convention on Biological Diversity (CBD)
  • Pre-plated in 384 well plates, as DMSO solutions, fully HTS compatible

Advanced Extracts Library

A collection of 21.200 pre-purified extracts (containing each from 5 to 10 compounds) including samples derived from microbial extracts, plants and mushroom fruit bodies.

Key features:

  • Bacterial sub-library: around 10.000 extracts, derived from nearly 3.300 individual microbial sources
  • Fungal sub-library: around 6.600 extracts, derived from around 2.850 distinct strains
  • Plant sub-library: around 3.200 extracts, derived from nearly 3.100 individual plant sources
  • Edible plants/mushrooms sub-library (edible library): around 1.400 extracts, derived from around 1.250 distinct species
  • Source distribution within the overall library: 31% bacteria, 27% fungi, 30% plants, 12% edibles
  • Adheres to the Convention on Biological Diversity (CBD)
  • Pre-plated in 96-well or 384-well plates, high HTS compatibility

Microbial Strain Library

A collection of 40,000 distinct strains from bacterial and fungal genetic sources.

Key features:

  • World leading collection of fungal and bacterial genetic sources
  • 40,000 distinct strains:
    – 30,600 bacterial cultures
    – 9,400 fungal cultures
  • Include identified producer strains for 2,559 different microbial metabolites:
    – 1,208 bacterial metabolites
    – 1,316 fungal metabolites
    – 35 metabolites

 

Bioprofiling

The IMAX Discovery database contains biological activity data derived from testing the NatPure, the PreFrac and Advanced Extracts libraries against more than 200 targets on various biochemical and cellular assays.
Bioprofiling can be used to address the initial phases of starting projects as well as support the results of more advanced projects.

Key features:

  • History of over 200 projects
  • Over 12 Million data points
  • References from the world’s largest collection of Natural Products

Synthetic compound collection, AXXDIV4.0

Besides the access to the natural compound collection, IMAX Discovery offers an entirely new generation screening collection composed of 325,000 synthetic compounds, carefully selected on the basis of Axxam’s broad screening expertise and with significant input from the company’s team of medicinal and computational chemists.
The AXXDIV4.0 library is not focused on a specific target class or chemical space built around a target class
but is rather diverse and meant to explore the highest diversity possible.
The compounds have been selected to be novel (available on the market for less than 6 years)
and multiple filters were applied in the selection process to exclude undesirable features.